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Phospho-MAP2K1/MAP2K2 (Ser222) Antibody (PA5-104956) in ICC/IF
Immunofluorescent analysis of Phospho-MAP2K1/MAP2K2 (Ser221) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-MAP2K1/MAP2K2 (Ser221) polyclonal antibody (Product # PA5-104956) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit Ig... View More
产品信息
PA5-104956
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human MAP2K1(Accession Q02750), corresponding to amino acid residues around phosphorylated Ser222.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816429
产品详细信息
Antibody detects endogenous levels of MEK1/2 only when phosphorylated at Ser222, which site historically referenced as Ser221.
靶标信息
MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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