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Phospho-MEK3/MEK6 (Ser189, Thr193) Polyclonal Antibody

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产品信息

PA5-114603

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human MKK3/MKK6 around the phosphorylation site of Ser189/Thr193.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2899239

产品详细信息

Antibody detects endogenous levels of MKK3/MKK6 only when phosphorylated at Ser189/Thr193.

靶标信息

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 3; MAP kinase kinase 6; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MEK 3; MEK 6; mitogen activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; OTTHUMP00000166044; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; SAPKK3; Stress-activated protein kinase kinase 2; Stress-activated protein kinase kinase 3

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基因别名: AW212142; MAP2K3; MAP2K6; MAPKK3; MAPKK6; MEK3; MEK6; MKK3; MKK6; mMKK3b; PRKMK3; PRKMK6; SAPKK-2; SAPKK-3; SAPKK2; SAPKK3; SKK2; SKK3

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UniProt ID: (Human) P46734, (Human) P52564, (Mouse) O09110, (Mouse) P70236

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Entrez Gene ID: (Human) 5606, (Human) 5608, (Mouse) 26397, (Rat) 303200, (Mouse) 26399, (Rat) 114495

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功能
receptor signaling protein serine/threonine kinase activity MAP kinase kinase activity protein tyrosine kinase activity protein binding ATP binding protein kinase binding nucleotide binding protein kinase activity protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
参与通路
MAPK cascade activation of MAPK activity inflammatory response signal transduction peptidyl-tyrosine phosphorylation proteolysis in other organism regulation of cytokine biosynthetic process positive regulation of protein kinase activity positive regulation of transcription, DNA-templated cardiac muscle contraction response to ischemia transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process DNA damage induced protein phosphorylation cell cycle arrest ovulation cycle process positive regulation of prostaglandin secretion response to drug positive regulation of apoptotic process positive regulation of nitric-oxide synthase biosynthetic process nucleotide-binding oligomerization domain containing signaling pathway cellular response to sorbitol protein phosphorylation regulation of mitotic cell cycle phosphorylation stress-activated protein kinase signaling cascade regulation of apoptotic process positive regulation of protein phosphorylation heart development cellular response to lipopolysaccharide regulation of signal transduction intracellular signal transduction
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