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产品信息
MA5-37014
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MSK1T581-A5
抗原
A synthetic phospho-peptide corresponding to residues surrounding Thr581 of human phospho MSK1.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2896949
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
RPS6KA5 (MSK1) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. RPS6KA5 is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 90 kDa ribosomal protein S6 kinase 5; kinase MSK1; KS6A5; mitogen and stress-activated protein kinase 1; Nuclear mitogen- and stress-activated protein kinase 1; Ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RLSK; RSK-like protein kinase; RSKL; S6K-alpha-5
基因别名: 3110005L17Rik; 6330404E13Rik; AI854034; MSK1; MSPK1; RLPK; RPS6KA5
UniProt ID: (Human) O75582, (Mouse) Q8C050
Entrez Gene ID: (Human) 9252, (Mouse) 73086, (Rat) 314384
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
histone kinase activity (H3-S10 specific)
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
negative regulation of cytokine production
stimulatory C-type lectin receptor signaling pathway
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
epidermal growth factor receptor signaling pathway
axon guidance
histone phosphorylation
positive regulation of CREB transcription factor activity
positive regulation of histone phosphorylation
positive regulation of histone acetylation
intracellular signal transduction
histone H3-S10 phosphorylation
histone H3-S28 phosphorylation
histone H2A-S1 phosphorylation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
phosphorylation
