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Phospho-MUNC18 (Ser241) Antibody (PA5-35398) in WB
Western blot of MUNC18 in mouse hippocampal lysate showing specific immunolabeling of a band at ~65 kDa corresponding to Phospho-MUNC18 (Ser241) polyclonal antibody (Product # PA5-35398) in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 min).
产品信息
PA5-35398
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 of mouse STXBP1 conjugated to KLH
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 0.1mg/mL BSA
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2552708
产品详细信息
This antibody is predicted to react with bovine, canine, chicken, human, non-human primate, rat and sheep based on 100% sequence homology.
This antibody contains enough material to conduct 10 mini-Western blots.
靶标信息
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; munc-18c; N-Sec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; UNC-18 homolog; unc-18-1; Unc-18A; Unc18-1
基因别名: AI317162; AI326233; ANC18HA; MMS10-G; Ms10g; Munc-18a; Munc18-1; N-sec1; nSec1; NSEC1A; Rb-sec1; rbSec1; rbSec1A; rbSec1B; Sec1; Stxbp1; Sxtbp1; Unc18-1; Unc18a; Unc18h
UniProt ID: (Mouse) O08599, (Rat) P61765
Entrez Gene ID: (Mouse) 20910, (Rat) 25558
platelet degranulation
transport
exocytosis
vesicle docking involved in exocytosis
neurotransmitter secretion
neuromuscular synaptic transmission
axon target recognition
regulation of synaptic vesicle priming
protein transport
synaptic vesicle maturation
vesicle-mediated transport
synaptic vesicle fusion to presynaptic active zone membrane
negative regulation of synaptic transmission, GABAergic
negative regulation of neuron apoptotic process
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
protein stabilization
long term synaptic depression
platelet aggregation
protein localization to plasma membrane
