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Phospho-NFkB-p100 (Ser866) Antibody (MA5-55231) in WB
Western blot analysis of lysates from NIH/3T3 cells, using Phospho-NFkB-p100 (Ser866) Recombinant Monoclonal Antibody (Product # MA5-55231) at 1:500 dilution. NIH/3T3 cells were treated by TNF-alpha (20 ng/mL) at 37&(8)451; for 30 minutes followed by a HRP-conjugated Goat anti-Rabbit IgG (H+L) secondary antibody at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in T... View More
产品信息
MA5-55231
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1J7E2
抗原
A synthetic phosphorylated peptide around S866 of human Phospho-NF-kB2-S866.
偶联物
形式
Liquid
浓度
0.52 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
产品详细信息
Immunogen Sequence: EDSAY
靶标信息
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA-binding factor KBF2; NF kappaB2; NF-kB p100; Nuclear factor NF-kappa-B p100 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100
基因别名: lyt; NF-kappaB2; Nfkb2; p49; p49/p100; p50B; p52
UniProt ID: (Mouse) Q9WTK5
Entrez Gene ID: (Mouse) 18034
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
Rel homology transcription factor
negative regulation of transcription from RNA polymerase II promoter
follicular dendritic cell differentiation
germinal center formation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
inflammatory response
signal transduction
I-kappaB kinase/NF-kappaB signaling
extracellular matrix organization
response to cytokine
NIK/NF-kappaB signaling
innate immune response
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
lymph node development
spleen development
