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Phospho-NFkB p105 (Ser903) Antibody (PA5-105756) in WB
Western blot analysis of Phospho-NFkB p105 (Ser903) in Jurkat cell lysate (absence (-) or presence (+) of non-phospho and phospho peptide). Samples were incubated with Phospho-NFkB p105 (Ser903) polyclonal antibody (Product # PA5-105756).
产品信息
PA5-105756
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NFKB1(Accession P19838), corresponding to amino acid residues around phosphorylated Ser903.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2817155
产品详细信息
Antibody detects endogenous levels of NF kappaB p105/p50 only when phosphorylated at Ser903.
靶标信息
NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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