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Phospho-Nuclear receptor ROR gamma (Ser203) Antibody (600-401-GR8) in WB
Western Blot of Rabbit anti-receptor ROR gamma pS203 antibody. Lane 1: Opal PreStained Ladder Lane 2: Wild-type Mouse Thymus. Lane 3: KO Mouse Thymus. Load: 10 µg per lane. Primary antibody: Receptor ROR gamma pS203 antibody at 1 µg/mL for overnight at 4°C. Secondary antibody: Peroxidase rabbit secondary antibody at 1:40,000 for 30 min at RT. Block: MB-070 for 30 minutes at RT. Predicted/Observed si... View More
产品信息
600-401-GR8
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Affinity purified Anti-receptor ROR gamma pS203 antibody was prepared from whole rabbit serum produced by repeated immunizations with an internal synthetic peptide phosphorylated at the serine 203 position of mouse receptor ROR gamma protein.
偶联物
形式
Liquid
浓度
1.05 mg/mL
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Anti-nuclear receptor ROR gamma pS203 is directed against mouse receptor ROR gamma phosphorylated at the serine 203 position. A BLAST analysis was used to suggest reactivity with this protein with pongo abelii based on 100% homology for the immunogen sequence.
靶标信息
ROR gamma is a 560 amino acid novel DNA-binding transcription factor belonging to the ROR/RZR orphan nuclear receptor subfamily. Reports suggest thatROR gammais a ligand activated transcription factor and may be essential for lymphoid organogenesis (lymph nodes and Peyer's patches) and may play an important regulatory role in controlling apoptosis during thymopoiesis. ROR gamma inhibits the expression of Fas ligand and IL2 and directs the differentiation program of proinflammatory IL-17+ T helper cells. ROR gamma shares 50 to 51% sequence identity with RORA and RORB and is 88% identical to mouse ROR gamma. It is highly expressed in skeletal muscle and at lower levels in various other tissues.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nuclear receptor ROR-gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma; Thymus orphan receptor; TOR
基因别名: Nr1f3; Rorc; Rorg; RORgamma; Thor; TOR
UniProt ID: (Mouse) P51450
Entrez Gene ID: (Mouse) 19885
transcription coactivator binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
oxysterol binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
transcription factor activity, direct ligand regulated sequence-specific DNA binding
C4 zinc finger nuclear receptor
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
xenobiotic metabolic process
multicellular organism development
regulation of glucose metabolic process
regulation of steroid metabolic process
cell differentiation
interleukin-17 production
circadian regulation of gene expression
T cell differentiation in thymus
cellular response to sterol
T-helper cell differentiation
positive regulation of circadian rhythm
steroid hormone mediated signaling pathway
regulation of gamma-delta T cell differentiation
regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
alpha-beta T cell differentiation
rhythmic process
lymph node development
mucosal-associated lymphoid tissue development
Peyer's patch development
adipose tissue development
regulation of transcription involved in cell fate commitment
negative regulation of thymocyte apoptotic process
T-helper 17 cell differentiation
