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Phospho-PABP (Tyr364) Antibody (PA5-105090) in WB
Western blot analysis of Phospho-PABP (Tyr364) in HCT116 cell lysate (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-PABP (Tyr364) polyclonal antibody (Product # PA5-105090).
产品信息
PA5-105090
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PABPC1(Accession P11940), corresponding to amino acid residues around phosphorylated Tyr364.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816563
产品详细信息
Antibody detects endogenous levels of PABP1 only when phosphorylated at Tyr364.
靶标信息
The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3 functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4), and PABP3 (PABPC3). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PABP 1; PABP-1; poly A binding protein 1; poly(A) binding protein, cytoplasmic 1; poly(A) binding protein, cytoplasmic 2; poly(A)-binding protein 1; Polyadenylate-binding protein 1
基因别名: ePAB; PAB1; PABP; PABP1; PABPC1; PABPC2; PabpI; PABPL1
UniProt ID: (Human) P11940, (Rat) Q9EPH8, (Mouse) P29341
Entrez Gene ID: (Human) 26986, (Rat) 171350, (Mouse) 18458
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA processing
RNA splicing
gene silencing by RNA
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
nuclear-transcribed mRNA poly(A) tail shortening
mRNA splicing, via spliceosome
mRNA polyadenylation
translational initiation
regulation of mRNA stability
positive regulation of viral genome replication
positive regulation of translation
mRNA stabilization
