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PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); Alpha-type platelet-derived growth factor receptor; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140 antigen-like family member B; CD140a; CD140a antigen; CD140b; MGC74795; PDGF alpha chain; PDGF beta chain; PDGF Receptor alpha; PDGF-R-alpha; PDGF-R-beta; PDGFR-1; PDGFR-2; pdgfr-a; PDGFR-alpha; PDGFR-beta; PDGFRA/BCR fusion; PGFRB; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor 2; Platelet-derived growth factor receptor alpha; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; platelet-derived growth factor receptor, alpha polypeptide; platelet-derived growth factor receptor, beta polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein
基因别名: AI115593; AI528809; CD140A; CD140B; GAS9; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR-2; PDGFR1; PDGFR2; PDGFRA; PDGFRB; PENTT; RHEPDGFRA
UniProt ID: (Human) P16234, (Human) P09619, (Mouse) P26618, (Mouse) P05622
Entrez Gene ID: (Human) 5156, (Human) 5159, (Mouse) 18595, (Mouse) 18596