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Phospho-PFKFB3 (Ser461) Antibody (PA5-114619) in ICC/IF
Immunocytochemistry analysis of Phospho-PFKFB3 (Ser461) in A549 cells (heat shock treatment). Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114619). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conj... View More
产品信息
PA5-114619
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PFKFB3 around the phosphorylation site of Ser461.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899255
产品详细信息
Antibody detects endogenous levels of PFKFB3 only when phosphorylated at Ser461.
靶标信息
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 6-biphosphatase 3; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; Fructose-2; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; iPFK-2; PFK/FBPase 3; RB2K; Renal carcinoma antigen NY-REN-56; RP11-298K24.3
基因别名: E330010H22Rik; iPFK-2; IPFK2; PFK2; PFKFB3; uPFK-2
UniProt ID: (Human) Q16875, (Rat) O35552
Entrez Gene ID: (Human) 5209, (Rat) 117276, (Mouse) 170768
