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Positive test controls include: NIH/3T3. The target is usually found in the following locations: Cytoplasm, Membrane, Nucleus, Peripheral membrane protein.
Immunogen sequence: VLTPP
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: aging-associated gene 6; PKC-A; PKC-alpha; PKC-B; PKC-beta; PRKC Pan; Protein kinase C alpha type; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C beta-II; protein kinase C, alpha; protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase c-alpha
基因别名: A130082F03Rik; AAG6; AI875142; PKC-alpha; PKC-Beta; PKCA; PKCB; PRKACA; PRKCA; PRKCB; PRKCB1; PRKCB2
UniProt ID: (Human) P17252, (Human) P05771, (Mouse) P20444, (Mouse) P68404, (Rat) P68403
Entrez Gene ID: (Human) 5578, (Human) 5579, (Mouse) 18750, (Rat) 24680, (Mouse) 18751, (Rat) 25023