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Phospho-PKC mu (Ser916) Antibody (PA5-117245) in WB
Western blot analysis of Phospho-PKC mu (Ser916) in extracts of HeLa cells. Samples were incubated with Phospho-PKC mu (Ser916) Polyclonal antibody (Product # PA5-117245) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-117245
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphorylated peptide around S912 of human PKC mu (NP_0027332)
偶联物
形式
Liquid
浓度
2.53 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901875
产品详细信息
Positive Samples: HeLa
Immunogen sequence: RVSIL
靶标信息
The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZP586E0820; nPKC-D1; nPKC-D2; nPKC-mu; nPKC-nu; PKC mu; PKC nu; PKC u; PKC v; PKC-u; PKC-v; PKCmu; PKCu; PKCv; Protein kinase C mu type; Protein kinase C nu type; protein kinase C, mu; protein kinase C, nu; Protein kinase D; Protein kinase EPK2; Serine/threonine-protein kinase D1; Serine/threonine-protein kinase D2; Serine/threonine-protein kinase D3
基因别名: 4930557O20Rik; 5730497N19Rik; AI325941; EPK2; HSPC187; nPKC-D2; nPKC-NU; PKC-MU; PKC-NU; PKCM; Pkcnu; PKD; PKD1; PKD2; PKD3; PRKCM; PRKCN; PRKD1; PRKD2; PRKD3
UniProt ID: (Human) Q15139, (Human) Q9BZL6, (Human) O94806, (Mouse) Q62101, (Mouse) Q8BZ03, (Mouse) Q8K1Y2
Entrez Gene ID: (Human) 5587, (Human) 25865, (Human) 23683, (Mouse) 18760, (Mouse) 101540, (Mouse) 75292
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
kinase activity
identical protein binding
metal ion binding
protein kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
angiogenesis
positive regulation of endothelial cell proliferation
protein phosphorylation
apoptotic process
inflammatory response
Golgi organization
signal transduction
integrin-mediated signaling pathway
Ras protein signal transduction
cell proliferation
positive regulation of endothelial cell migration
regulation of keratinocyte proliferation
positive regulation of neuron projection development
peptidyl-serine phosphorylation
sphingolipid biosynthetic process
regulation of protein stability
positive regulation of CREB transcription factor activity
positive regulation of peptidyl-serine phosphorylation
cellular response to oxidative stress
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of blood vessel endothelial cell migration
innate immune response
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
negative regulation of endocytosis
positive regulation of transcription from RNA polymerase II promoter
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
Golgi vesicle transport
positive regulation of NF-kappaB transcription factor activity
regulation of release of sequestered calcium ion into cytosol
negative regulation of cell death
protein kinase D signaling
positive regulation of histone deacetylase activity
positive regulation of endothelial cell chemotaxis
regulation of integrin-mediated signaling pathway
adaptive immune response
cell adhesion
cell death
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of interleukin-2 production
positive regulation of interleukin-8 production
positive regulation of fibroblast growth factor receptor signaling pathway
positive regulation of cell adhesion
T cell receptor signaling pathway
positive regulation of T cell receptor signaling pathway
positive regulation of sequence-specific DNA binding transcription factor activity
endothelial tube morphogenesis
positive regulation of ERK1 and ERK2 cascade
mitophagy in response to mitochondrial depolarization
positive regulation of intracellular signal transduction
positive regulation of DNA biosynthetic process
protein kinase C-activating G-protein coupled receptor signaling pathway
immune system process
nervous system development
phosphorylation
cell differentiation
