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Phospho-PKC mu (Tyr463) Antibody (PA5-104995) in ICC/IF
Immunofluorescent analysis of Phospho-PKC mu (Tyr463) in HeLa cells(4h of LPS treatment). Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-PKC mu (Tyr463) polyclonal antibody (Product # PA5-104995) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor ... View More
产品信息
PA5-104995
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PRKD1(Accession Q15139), corresponding to amino acid residues around phosphorylated Tyr463.
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816468
产品详细信息
Antibody detects endogenous levels of PKD1/PKC mu only when phosphorylated at Tyrosine 463.
靶标信息
The PKC family of serine/threonine kinases, including PRKCN (PKD3), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC mu activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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