Invitrogen

Phospho-PKM2 (Ser37) Polyclonal Antibody

Phospho-PKM2 (Ser37) Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 3

Phospho-PKM2 (Ser37) Antibody (PA5-37684) in ICC/IF

Immunocytochemical analysis of Phospho-PKM2 (Ser37) in methanol-fixed MEF cells, using Phospho-PKM2 (Ser37) Polyclonal Antibody (Product # PA5-37684).

Phospho-PKM2 (Ser37) Antibody in Western Blot (WB)

Product Image Gallery

产品信息

PA5-37684

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看4篇已发表文章 4篇已发表文章

免疫细胞化学 (ICC/IF)

1:100-1:200

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of serine 37(I-D-S(p)-P-P) derived from Human PKM2.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

Dulbecco's PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2554292

产品详细信息

A suggested positive control for ICC/IF is MEF cells.

靶标信息

PKM2 is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. PKM2 has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. PKM2 has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms of PKM2 have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury.

International journal of molecular sciences

Gill NB,Dowker-Key PD,Hubbard K,Voy BH,Whelan J,Hedrick M,Bettaieb A

PA5-37684 was used in Western Blot to investigate the effects of ginsenoside Rc (G-Rc) on UB/OC-2 primary murine sensory hair cell survival in response to palmitate-induced injury.

Sun Apr 16 00:00:00 UTC 2023

Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin.

Cell communication and signaling : CCS

Alquraishi M,Chahed S,Alani D,Puckett DL,Dowker PD,Hubbard K,Zhao Y,Kim JY,Nodit L,Fatima H,Donohoe D,Voy B,Chowanadisai W,Bettaieb A

PA5-37684 was used in Western Blot to demonstrate that PKM2 plays a key role in podocyte injury and suggests that targetting PKM2 in podocytes could serve as a promising therapeutic strategy for AKI.

Mon May 30 00:00:00 UTC 2022

Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.

Cell death & disease

Wang C,Zeng J,Li LJ,Xue M,He SL

PA5-37684 was used in Western Blot to reveal that Cdc25A/PKM2/ErbB2 pathway-regulated ferroptosis could serve as a therapeutic target in cervical cancer.

Sat Nov 06 00:00:00 UTC 2021

Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells.

Cell death & disease

Wang C,Zeng J,Li LJ,Xue M,He SL

PA5-37684 was used in Western Blot to reveal that Cdc25A/PKM2/ErbB2 pathway-regulated ferroptosis could serve as a therapeutic target in cervical cancer.

Sat Nov 06 00:00:00 UTC 2021

PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC.

Frontiers in pharmacology

Wang X,Liang C,Yao X,Yang RH,Zhang ZS,Liu FY,Li WQ,Pei SH,Ma J,Xie SQ,Fang D

PA5-37684 was used in Western Blot to study whether pyruvate kinase isoform M2 (PKM2) was involved in regulating programmed death-ligand-1 (PD-L1) expression in hepatocellular carcinoma.

Mon Aug 02 00:00:00 UTC 2021

PKM2-Induced the Phosphorylation of Histone H3 Contributes to EGF-Mediated PD-L1 Transcription in HCC.

Frontiers in pharmacology

Wang X,Liang C,Yao X,Yang RH,Zhang ZS,Liu FY,Li WQ,Pei SH,Ma J,Xie SQ,Fang D

PA5-37684 was used in Western Blot to study whether pyruvate kinase isoform M2 (PKM2) was involved in regulating programmed death-ligand-1 (PD-L1) expression in hepatocellular carcinoma.

Mon Aug 02 00:00:00 UTC 2021

生物信息学

蛋白别名: CTHBP; Cytosolic thyroid hormone-binding protein; epididymis secretory protein Li 30; isozymes M1/M2; m2pk; OIP-3; OPA-interacting protein 3; p58; PK, muscle type; Pyruvate kinase 2/3; pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle isozyme; Pyruvate kinase PKM; THBP1; Threonine-protein kinase PKM2; Thyroid hormone-binding protein 1; thyroid hormone-binding protein, cytosolic; tu; Tumor M2-PK; Tyrosine-protein kinase PKM2

查看更多收起

基因别名: CTHBP; HEL-S-30; OIP3; PK2; PK3; PKM; PKM2; TCB; THBP1

查看更多收起

UniProt ID: (Human) P14618

查看更多收起

Entrez Gene ID: (Human) 5315

查看更多收起

功能