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Phospho-PLA2G4A (Ser505) Antibody (PA5-17790) in WB
Western blot was performed using Anti-PLA2G4A Polyclonal Antibody (Product # PA5-17790) and a ~85 kDa band was observed across the panel tested except IMR-32 and Reh. Whole cell extracts (30 µg lysate) of HeLa (Lane 1), A549 (Lane 2), NIH/3T3 (Lane 3), IMR-32 (Lane 4) and Reh (Lane 5) were electrophoresed using NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a... View More
产品信息
PA5-17790
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to residues surrounding pSer505 of human cPLA2
偶联物
形式
Liquid
浓度
250 µg/mL
纯化类型
Antigen affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10985549
产品详细信息
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with the secreted PLA2 (sPLA2) or cytosolic Ca2+ independent PLA2 (iPLA2).
靶标信息
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcium-dependent phospholipid-binding protein; cPLA2; cytosolic group IVA; Cytosolic phospholipase A2; group IVA; Lysophospholipase; MGC126350; Phosphatidylcholine 2-acylhydrolase; Phospholipase A2; phospholipase A2 cytosolic; Phospholipase A2 group IVA; phospholipase A2, group IVA (cytosolic, calcium-dependent)
基因别名: CPLA2; cPLA2-alpha; cPLA2alpha; Pla2c; PLA2G4; PLA2G4A
UniProt ID: (Human) P47712, (Mouse) P47713
Entrez Gene ID: (Human) 5321, (Mouse) 18783, (Rat) 24653
ovulation from ovarian follicle
luteolysis
phospholipid metabolic process
phosphatidic acid biosynthetic process
platelet activating factor biosynthetic process
icosanoid metabolic process
aging
positive regulation of cell proliferation
phospholipid catabolic process
response to heat
response to lithium ion
response to organonitrogen compound
arachidonic acid metabolic process
positive regulation of bone mineralization
positive regulation of vesicle fusion
positive regulation of prostaglandin biosynthetic process
positive regulation of fever generation
response to lipopolysaccharide
response to vitamin D
cardiolipin acyl-chain remodeling
phosphatidylglycerol acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
response to hydrogen peroxide
positive regulation of apoptotic process
surfactant homeostasis
icosanoid biosynthetic process
decidualization
arachidonic acid secretion
response to glucocorticoid
response to calcium ion
response to methylmercury
cellular response to antibiotic
response to hormone
response to organic substance
regulation of cell proliferation
positive regulation of inflammatory response
