Invitrogen

Phospho-PSEN2 (Ser330) Polyclonal Antibody

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抗体检测数据 (1)

Phospho-PSEN2 (Ser330) Antibody in Western Blot (WB)

Phospho-PSEN2 (Ser330) Antibody in Western Blot (WB)

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Phospho-PSEN2 (Ser330) Antibody (PA5-105831) in WB

Western blot analysis of Phospho-PSEN2 (Ser330) in extracts from Mouse kidney. Samples were incubated with Phospho-PSEN2 (Ser330) polyclonal antibody (Product # PA5-105831). The lane on the left was treated with blocking peptide.

Phospho-PSEN2 (Ser330) Antibody in Western Blot (WB)

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Phospho-PSEN2 (Ser330) Antibody in Western Blot (WB) — Western blot analysis of Phospho-PSEN2 (Ser330) in extracts from Mouse kidney. Samples were incubated with Phospho-PSEN2 (Ser330) polyclonal antibody (Product # PA5-105831). The lane on the left was treated with blocking peptide.

产品信息

PA5-105831

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human PSEN2(Accession P49810), corresponding to amino acid residues around phosphorylated Ser330.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2817230

产品详细信息

Antibody detects endogenous levels of Presenilin 2 only when phosphorylated at Ser330.

靶标信息

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AD3LP; AD5; Alzheimer disease 4; E5-1; Presenilin-2; PS-2; PSEN 2; STM-2

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基因别名: AD3L; AD4; Ad4h; ALG-3; Alg3; CMD1V; PS-2; PS2; PSEN2; PSNL2; STM2

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UniProt ID: (Human) P49810, (Rat) O88777, (Mouse) Q61144

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Entrez Gene ID: (Human) 5664, (Rat) 81751, (Mouse) 19165

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endopeptidase activity aspartic-type endopeptidase activity protein binding molecular_function peptidase activity hydrolase activity aspartic endopeptidase activity, intramembrane cleaving aspartic protease

response to hypoxia membrane protein ectodomain proteolysis calcium ion transport Notch signaling pathway Notch receptor processing protein processing membrane protein intracellular domain proteolysis intracellular signal transduction amyloid precursor protein catabolic process positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of catalytic activity ephrin receptor signaling pathway beta-amyloid metabolic process negative regulation of transcription from RNA polymerase II promoter cell fate specification somitogenesis positive regulation of receptor recycling negative regulation of protein phosphorylation hair follicle development hematopoietic progenitor cell differentiation T cell activation involved in immune response myeloid leukocyte differentiation proteolysis negative regulation of epidermal growth factor-activated receptor activity regulation of epidermal growth factor-activated receptor activity learning or memory memory protein transport dorsal/ventral neural tube patterning embryonic limb morphogenesis forebrain development negative regulation of protein complex assembly negative regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process endoplasmic reticulum calcium ion homeostasis locomotion regulation of protein binding skin morphogenesis cellular protein metabolic process regulation of synaptic plasticity lung alveolus development thymus development brain morphogenesis positive regulation of coagulation T cell receptor signaling pathway negative regulation of ubiquitin-protein transferase activity protein maturation cardiac muscle contraction negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process negative regulation of apoptotic signaling pathway embryo development anagen