Invitrogen

Phospho-RARA/RARB (Ser96) Polyclonal Antibody

查看其他3个RARA/RARB抗体

产品信息

PA5-64622

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human Retinoic Acid Receptor alpha/beta (Phospho-Ser96)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2662518

产品详细信息

Phospho-RARA/RARB (Ser96) Polyclonal Antibody detects endogenous levels of RARA/RARB only when phosphorylated at Ser96.

靶标信息

Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR alpha 1; RAR-alpha; RAR-beta; RAR-epsilon; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; Retinoic acid receptor alpha; Retinoic acid receptor beta; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide

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基因别名: A830025K23; HAP; MCOPS12; NR1B1; NR1B2; RAR; RARA; RARalpha1; RARB; RARbeta1; RRB2

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UniProt ID: (Human) P10276, (Human) P10826, (Mouse) P11416, (Mouse) P22605

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Entrez Gene ID: (Human) 5914, (Human) 5915, (Rat) 24705, (Mouse) 19401, (Rat) 24706, (Mouse) 218772

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translation repressor activity, nucleic acid binding RNA polymerase II regulatory region sequence-specific DNA binding retinoic acid binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity transcription corepressor activity receptor binding protein binding transcription factor binding drug binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding retinoic acid-responsive element binding protein heterodimerization activity mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding DNA binding protein complex binding retinoid X receptor binding RNA polymerase II regulatory region DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding phosphatidylinositol 3-kinase regulator activity sequence-specific DNA binding transcription regulatory region DNA binding regulatory region DNA binding metal ion binding C4 zinc finger nuclear receptor

negative regulation of transcription from RNA polymerase II promoter ureteric bud development neural tube closure liver development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development transcription initiation from RNA polymerase II promoter protein phosphorylation signal transduction germ cell development spermatogenesis female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation hippocampus development prostate gland development negative regulation of granulocyte differentiation embryonic camera-type eye development regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine multicellular organism growth negative regulation of apoptotic process apoptotic cell clearance steroid hormone mediated signaling pathway response to ethanol positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of translational initiation regulation of synaptic plasticity retinoic acid receptor signaling pathway positive regulation of binding ventricular cardiac muscle cell differentiation Sertoli cell fate commitment limb development face development trachea cartilage development chondroblast differentiation negative regulation of cartilage development cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus retinal pigment epithelium development striatum development negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis positive regulation of apoptotic process embryonic eye morphogenesis embryonic digestive tract development transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter male gonad development positive regulation of gene expression negative regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of translation intracellular estrogen receptor signaling pathway regulation of granulocyte differentiation regulation of apoptotic process regulation of phosphatidylinositol 3-kinase activity negative regulation of cell differentiation positive regulation of protein kinase B signaling bone development positive regulation of ERK1 and ERK2 cascade neurogenesis positive regulation of programmed cell death retina development in camera-type eye regulation of transcription from RNA polymerase II promoter