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Phospho-RSK2 (Tyr529) Antibody (PA5-118784) in IHC (P)
Immunohistochemical analysis of Phospho-RSK2 (Tyr529) in Human esophageal cancer using a Phospho-RSK2 (Tyr529) polyclonal antibody (Product # PA5-118784). The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the primary antibody at 4°C overnight. An HRP conjugated anti-Rabbit antibody was used as the seco... View More
产品信息
PA5-118784
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RPS6KA3(Accession P51812), corresponding to amino acid residues around phosphorylated Tyr529.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903284
产品详细信息
Antibody detects endogenous levels of RSK2 only when phosphorylated at Tyr529.
靶标信息
RPS6KA3 (RSK2) is a serine/threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation. RPS6KA3 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in the gene have been associated with Coffin-Lowry syndrome (CLS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 90 kDa ribosomal protein S6 kinase 3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; p90-RSK 3; pp90RSK2; ribosomal protein S6 kinase 2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RSK-2; S6K-alpha-3
基因别名: C130006E23; CLS; HU-3; ISPK-1; ISPK1; MAPKAPK-1b; MAPKAPK1B; MPK-9; MRX19; p90-RSK2; p90RSK3; pp90RSK2; RGD1563860; Rps6ka-rs1; RPS6KA3; RSK; RSK2; S6K-alpha3
UniProt ID: (Human) P51812, (Mouse) P18654
Entrez Gene ID: (Human) 6197, (Mouse) 110651, (Rat) 501560
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
protein kinase binding
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
nucleotide binding
ribosomal protein S6 kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
protein modifying enzyme
skeletal system development
toll-like receptor signaling pathway
protein phosphorylation
apoptotic process
cell cycle
signal transduction
central nervous system development
positive regulation of cell growth
response to lipopolysaccharide
intracellular signal transduction
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of translation in response to stress
regulation of DNA-templated transcription in response to stress
positive regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of translation
phosphorylation
biological_process
