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Phospho-Synaptotagmin 1/2 (Ser309) Antibody (PA5-104839) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-Synaptotagmin 1 (Ser309) in human Thyroid cancer tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-Synaptotagmin 1 (Ser309) polyclonal antibody (Product # PA5-104839) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rab... View More
产品信息
PA5-104839
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human SYT1(Accession P21579), corresponding to amino acid residues around phosphorylated Ser309.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816312
产品详细信息
Antibody detects endogenous levels of Synaptotagmin 1/2 only when phosphorylated at Serine 309.
靶标信息
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ42519; Inositol polyphosphate-binding protein; IP4-binding protein; p65; synaptotagmin 1; synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; Synaptotagmin-1; Synaptotagmin-2; SytI; SytII
基因别名: AW124717; CMS7; G630098F17Rik; mKIAA4194; MYSPC; P65; R74640; RATSYNII; SVP65; SYNII; SYT; SYT1; SYT2; SytI; SytII
UniProt ID: (Human) P21579, (Human) Q8N9I0, (Rat) P21707, (Mouse) P46096, (Rat) P29101, (Mouse) P46097
Entrez Gene ID: (Human) 6857, (Human) 127833, (Rat) 25716, (Mouse) 20979, (Rat) 24805, (Mouse) 20980
SNARE binding
phosphatidylserine binding
calcium ion binding
protein binding
calmodulin binding
calcium-dependent phospholipid binding
1-phosphatidylinositol binding
phosphatidylinositol-4,5-bisphosphate binding
protein C-terminus binding
syntaxin-1 binding
clathrin binding
identical protein binding
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
syntaxin binding
inositol 1,3,4,5 tetrakisphosphate binding
transporter activity
phospholipid binding
metal ion binding
membrane trafficking regulatory protein
detection of calcium ion
vesicle fusion
chemical synaptic transmission
neurotransmitter secretion
brain development
glutamate secretion
regulation of exocytosis
regulation of calcium ion-dependent exocytosis
positive regulation of vesicle fusion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
synaptic vesicle endocytosis
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of synaptic transmission
protein homooligomerization
regulation of synaptic transmission, glutamatergic
cellular response to calcium ion
fast, calcium ion-dependent exocytosis of neurotransmitter
regulation of regulated secretory pathway
positive regulation of dendrite extension
synaptic vesicle exocytosis
calcium ion regulated exocytosis
response to calcium ion
transport
