Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Phospho-Synaptotagmin 1/2 (Thr202) Polyclonal Antibody
FIGURE: 1 / 2
Phospho-Synaptotagmin 1/2 (Thr202) Antibody (PA5-118546) in IHC (P)
Immunohistochemical analysis of Phospho-Synaptotagmin 1/2 (Thr202) in human Thyroid cancer tissue using a Phospho-Synaptotagmin 1/2 (Thr202) polyclonal antibody (Product # PA5-118546). The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabb... View More
Product Details
PA5-118546
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SYT1(Accession P21579), corresponding to amino acid residues around phosphorylated Thr202.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903048
Product Specific Information
Antibody detects endogenous levels of Synaptotagmin 1/2 only when phosphorylated at Threonine 202.
Target Information
Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FLJ42519; Inositol polyphosphate-binding protein; IP4-binding protein; p65; synaptotagmin 1; synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; Synaptotagmin-1; Synaptotagmin-2; SytI; SytII
Gene Aliases: AW124717; CMS7; G630098F17Rik; mKIAA4194; MYSPC; P65; R74640; RATSYNII; SVP65; SYNII; SYT; SYT1; SYT2; SytI; SytII
UniProt ID: (Human) P21579, (Human) Q8N9I0, (Rat) P21707, (Mouse) P46096, (Rat) P29101, (Mouse) P46097
Entrez Gene ID: (Human) 6857, (Human) 127833, (Rat) 25716, (Mouse) 20979, (Rat) 24805, (Mouse) 20980
SNARE binding
phosphatidylserine binding
calcium ion binding
protein binding
calmodulin binding
calcium-dependent phospholipid binding
1-phosphatidylinositol binding
phosphatidylinositol-4,5-bisphosphate binding
protein C-terminus binding
syntaxin-1 binding
clathrin binding
identical protein binding
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
syntaxin binding
inositol 1,3,4,5 tetrakisphosphate binding
transporter activity
phospholipid binding
metal ion binding
membrane trafficking regulatory protein
detection of calcium ion
vesicle fusion
chemical synaptic transmission
neurotransmitter secretion
brain development
glutamate secretion
regulation of exocytosis
regulation of calcium ion-dependent exocytosis
positive regulation of vesicle fusion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
synaptic vesicle endocytosis
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of synaptic transmission
protein homooligomerization
regulation of synaptic transmission, glutamatergic
cellular response to calcium ion
fast, calcium ion-dependent exocytosis of neurotransmitter
regulation of regulated secretory pathway
positive regulation of dendrite extension
synaptic vesicle exocytosis
calcium ion regulated exocytosis
response to calcium ion
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support