Invitrogen

Phospho-TGFBR1 (Ser165) Polyclonal Antibody

Phospho-TGFBR1 (Ser165) Antibody in Western Blot (WB)

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Phospho-TGFBR1 (Ser165) Antibody (PA5-40298) in WB

Scientific reports 2020 - Smad2/3 activation plays an important role in differentiation of DFAT cells into mural cells. ( A , B ) Western blotting analysis for phospho-TGFBR1 and phospho-Smad2 expression in DFAT cells. Protein expression of phospho-TGFBR1, phospho-Smad2 in DFAT cells in the presence of TGF-beta1 and a Smad2/3 inhibitor PD169316 ( A ). Effects of PD169316 in different doses on phospho-Smad2 in DFAT cells ( B ). ( C -... View More

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产品信息

PA5-40298

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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酶联免疫吸附实验 (ELISA)

1:5,000

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human TGFbeta RI around the phosphorylation site of S165.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2607325

产品详细信息

This antibody is predicted to react with human and rat based on sequence homology.

靶标信息

TGFBR1 is a transmembrane serine/threonine kinase in the TGFBR1 superfamily, which also includes ACVRs and BMPRs. Upon binding TGF-b, TGFBR2 dimerizes with and activates TGFBR1 via phosphorylation leading to downstream phosphorylation of SMADs by TGFBR1. TGFBR1 forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Inhibition of Sphingosine-1-Phosphate Receptor 2 by JTE013 Enhanced Alveolar Bone Regeneration by Promoting Angiogenesis.

International journal of molecular sciences

Lory W,Wellslager B,Sun C,Yilmaz Ö,Yu H

PA5-40298 was used in Western Blotting to support that inhibition of S1PR2 by JTE013 increased TGFβ/Smad and Akt signaling; enhanced VEGFA, PDGFA, and GDF15 gene expression; and subsequently promoted angiogenesis and alveolar bone regeneration.

Wed Feb 08 00:00:00 UTC 2023

MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses.

Mucosal immunology

Milara J,Ballester B,Safont MJ,Artigues E,Escrivá J,Morcillo E,Cortijo J

PA5-40298 was used in Western Blot to show that MUC4 expression is enhanced in IPF and promotes fibrotic processes in collaboration with TGF-β1 canonical pathway that could be an attractive druggable target for human IPF.

Mon Mar 01 00:00:00 UTC 2021

MUC4 is overexpressed in idiopathic pulmonary fibrosis and collaborates with transforming growth factor β inducing fibrotic responses.

Mucosal immunology

Milara J,Ballester B,Safont MJ,Artigues E,Escrivá J,Morcillo E,Cortijo J

Mon Mar 01 00:00:00 UTC 2021

Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation.

The Biochemical journal

Ghiroldi A,Piccoli M,Creo P,Cirillo F,Rota P,D'Imperio S,Ciconte G,Monasky MM,Micaglio E,Garatti A,Aureli M,Carsana EV,Menicanti L,Pappone C,Anastasia L

PA5-40298 was used in Western Blot to identify pro-fibrotic pathways in primary cultures of human cardiac fibroblasts as targets for cardiac fibrosis.

Fri Sep 18 00:00:00 UTC 2020

Activation of BK Channels Prevents Hepatic Stellate Cell Activation and Liver Fibrosis Through the Suppression of TGFβ1/SMAD3 and JAK/STAT3 Profibrotic Signaling Pathways.

Frontiers in pharmacology

Yang L,Han B,Zhang M,Wang YH,Tao K,Zhu MX,He K,Zhang ZG,Hou S

Published figure using Phospho-TGFBR1 (Ser165) polyclonal antibody (Product # PA5-40298) in Western Blot

Mon Sep 28 00:00:00 UTC 2020

The neovascularization effect of dedifferentiated fat cells.

Scientific reports

Watanabe H,Goto S,Kato R,Komiyama S,Nagaoka Y,Kazama T,Yamamoto C,Li Y,Konuma N,Hagikura K,Matsumoto T

PA5-40298 was used in Western Blotting to observe the therapeutic angiogenic effects of DFAT cells by the secretion of angiogenic factors and pericyte differentiation by transforming growth factor β1 signalling via Smad2/3.

Mon Jun 08 00:00:00 UTC 2020

The neovascularization effect of dedifferentiated fat cells.

Scientific reports

Watanabe H,Goto S,Kato R,Komiyama S,Nagaoka Y,Kazama T,Yamamoto C,Li Y,Konuma N,Hagikura K,Matsumoto T

Mon Jun 08 00:00:00 UTC 2020

Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases.

Communications biology

Wang K,Wang X,Hou Y,Zhou H,Mai K,He G

PA5-40298 was used in Western Blotting to study the mechanism by which receptor tyrosine kinases inhibition triggers cancer cell apoptosis.

Thu Apr 23 00:00:00 UTC 2020

生物信息学

蛋白别名: activin A receptor type II-like kinase, 53kDa; Activin A receptor type II-like protein kinase of 53kD; Activin receptor-like kinase 5; ALK-5; ESK2; mutant transforming growth factor beta receptor I; ser; Serine/threonine-protein kinase receptor R4; SKR4; tgf beta receptor 1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; TGFR1; Transfor; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I; Transforming growth factor-beta receptor type I

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基因别名: AAT5; ACVRLK4; ALK-5; ALK5; AU017191; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; TbetaR-I; TbetaRI; TGFBR1; TGFR-1

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UniProt ID: (Human) P36897, (Rat) P80204, (Mouse) Q64729

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Entrez Gene ID: (Human) 7046, (Rat) 29591, (Mouse) 21812

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功能