Invitrogen

Phospho-TOB1 (Ser164) Polyclonal Antibody

Phospho-TOB1 (Ser164) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-TOB1 (Ser164) Antibody (PA5-105180) in IHC (P)

Immunohistochemistry analysis of Phospho-TOB1 (Ser164) in mouse liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-TOB1 (Ser164) polyclonal antibody (Product # PA5-105180) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

Phospho-TOB1 (Ser164) Antibody in Western Blot (WB)

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产品信息

PA5-105180

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:2,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human TOB1(Accession P50616), corresponding to amino acid residues around phosphorylated Ser164.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2816653

产品详细信息

Antibody detects endogenous levels of TOB1 only when phosphorylated at Ser164.

靶标信息

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。