Invitrogen

Phospho-TrkA/TrkB (Tyr674, Tyr675, Tyr706, Tyr707) Polyclonal Antibody

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实验方案
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产品信息

PA5-121285

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:100-1:500
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic phosphorylated peptide around Y674 & Y675 of human TrkANTRK1 (NP_0010123311)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.01% thimerosal

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2914857

产品详细信息

Positive test controls include: HeLa.

Immunogen sequence: TDYYRV

靶标信息

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

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仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; Oncogene TRK; p140-TrkA; Trk-A; Trk-B; TRK1-transforming tyrosine kinase protein; TrkB tyrosine kinase; Tropomyosin-related kinase A; Tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B

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基因别名: GP145-TrkB; MTC; NTRK1; NTRK2; p140-TrkA; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB

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UniProt ID: (Human) P04629, (Human) Q16620

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Entrez Gene ID: (Human) 4914, (Human) 4915

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功能
transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase binding protein homodimerization activity neurotrophin binding nerve growth factor binding receptor tyrosine kinase binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity immunoglobulin superfamily cell adhesion molecule transmembrane signal receptor
参与通路
activation of MAPKK activity positive regulation of protein phosphorylation protein phosphorylation microtubule-based movement axon guidance aging learning or memory circadian rhythm negative regulation of cell proliferation response to radiation programmed cell death involved in cell development positive regulation of neuron projection development response to activity peptidyl-tyrosine phosphorylation olfactory nerve development B cell differentiation response to nutrient levels nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity response to ethanol positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling sympathetic nervous system development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to hydrostatic pressure response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to nerve growth factor stimulus vasculogenesis neuron migration inflammatory response neuromuscular junction development learning long-term memory feeding behavior positive regulation of cell proliferation response to light stimulus positive regulation of gene expression response to auditory stimulus glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway regulation of GTPase activity positive regulation of MAPK cascade retinal rod cell development regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis
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