Invitrogen

Phospho-TrkA/TrkB (Tyr674, Tyr675, Tyr706, Tyr707) Polyclonal Antibody

View all (6) TrkA/TrkB antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-121285

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:500
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around Y674 & Y675 of human TrkANTRK1 (NP_0010123311)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914857

Product Specific Information

Positive test controls include: HeLa.

Immunogen sequence: TDYYRV

Target Information

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; Oncogene TRK; p140-TrkA; Trk-A; Trk-B; TRK1-transforming tyrosine kinase protein; TrkB tyrosine kinase; Tropomyosin-related kinase A; Tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B

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Gene Aliases: GP145-TrkB; MTC; NTRK1; NTRK2; p140-TrkA; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB

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UniProt ID: (Human) P04629, (Human) Q16620

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Entrez Gene ID: (Human) 4914, (Human) 4915

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Function(s)
transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase binding protein homodimerization activity neurotrophin binding nerve growth factor binding receptor tyrosine kinase binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity immunoglobulin superfamily cell adhesion molecule transmembrane signal receptor
Process(es)
activation of MAPKK activity positive regulation of protein phosphorylation protein phosphorylation microtubule-based movement axon guidance aging learning or memory circadian rhythm negative regulation of cell proliferation response to radiation programmed cell death involved in cell development positive regulation of neuron projection development response to activity peptidyl-tyrosine phosphorylation olfactory nerve development B cell differentiation response to nutrient levels nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity response to ethanol positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling sympathetic nervous system development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to hydrostatic pressure response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to nerve growth factor stimulus vasculogenesis neuron migration inflammatory response neuromuscular junction development learning long-term memory feeding behavior positive regulation of cell proliferation response to light stimulus positive regulation of gene expression response to auditory stimulus glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway regulation of GTPase activity positive regulation of MAPK cascade retinal rod cell development regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis
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