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Phospho-USP22 (Thr147) Antibody (PA5-105351) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-USP22 (Thr147) in mouse spleen tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-USP22 (Thr147) polyclonal antibody (Product # PA5-105351) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-105351
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human USP22(Accession Q9UPT9), corresponding to amino acid residues around phosphorylated Thr147.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816779
产品详细信息
Antibody detects endogenous levels of USP22 only when phosphorylated at Thr147.
靶标信息
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22
基因别名: AI427806; KIAA1063; USP22; USP3L
UniProt ID: (Human) Q9UPT9, (Mouse) Q5DU02
Entrez Gene ID: (Human) 23326, (Mouse) 216825, (Rat) 303201
transcription coactivator activity
thiol-dependent ubiquitin-specific protease activity
protein binding
zinc ion binding
H4 histone acetyltransferase activity
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
cysteine-type endopeptidase activity
peptidase activity
cysteine-type peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
metal ion binding
molecular_function
cysteine protease
transcription, DNA-templated
ubiquitin-dependent protein catabolic process
cell cycle
embryo development
histone ubiquitination
histone deubiquitination
protein deubiquitination
histone H4 acetylation
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
regulation of transcription, DNA-templated
proteolysis
chromatin modification
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
biological_process
