Invitrogen

Phospho-VEGF Receptor 2 (Tyr996) Polyclonal Antibody

查看其他50个FLK1 (VEGF Receptor 2)抗体
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实验方案
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产品信息

PA5-105765

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human KDR(Accession P35968), corresponding to amino acid residues around phosphorylated Tyr996.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2817164

产品详细信息

Antibody detects endogenous levels of VEGFR2 only when phosphorylated at Tyr996.

靶标信息

KDR (FLK1, VEGFR2) is a type III receptor tyrosine kinase. It binds vascular endothelial growth factor with high affinity in vitro, and is expressed early in development by endothelial cell precursors. FLK1 (VEGF Receptor 2) encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc. Mutations of FLK1 (VEGF Receptor 2) are implicated in infantile capillary hemangiomas.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD309; CD309 antigen; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); KDR; kinase insert domain protein receptor; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Kinase NYK; Protein-tyrosine kinase receptor flk-1; sCD309; soluble CD309; soluble vascular endothelial growth factor receptor 2; soluble VEGFR 2; soluble VEGFR2; tyrosine kinase growth factor receptor; Vascular endothelial growth factor receptor 2; vascular endothelial growth factor receptor- 2; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; VEGF R2; VEGF receptor-2; VEGFR-2

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基因别名: 6130401C07; CD309; Flk-1; FLK1; KDR; Krd-1; Ly73; sVEGFR-2; VEGFR; VEGFR-2; VEGFR2

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UniProt ID: (Human) P35968, (Rat) O08775, (Mouse) P35918

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Entrez Gene ID: (Human) 3791, (Rat) 25589, (Mouse) 16542

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功能
protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity integrin binding protein binding ATP binding growth factor binding Hsp90 protein binding vascular endothelial growth factor binding nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
参与通路
angiogenesis vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis endothelium development transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation regulation of cell shape positive regulation of endothelial cell migration positive regulation of phosphatidylinositol 3-kinase signaling viral process positive regulation of macroautophagy peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation extracellular matrix organization positive regulation of cell migration embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source cellular response to vascular endothelial growth factor stimulus positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization positive regulation of ERK1 and ERK2 cascade positive regulation of mitochondrial fission negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis ovarian follicle development response to hypoxia lymph vessel development positive regulation of mesenchymal cell proliferation endocardium development endochondral bone growth positive regulation of cytosolic calcium ion concentration aging male gonad development cell migration hemopoiesis hyaluronan metabolic process lung development positive regulation of BMP signaling pathway positive regulation of TOR signaling vascular endothelial growth factor signaling pathway response to drug surfactant homeostasis negative regulation of neuron apoptotic process cell fate commitment endothelial cell differentiation regulation of endothelial cell differentiation positive regulation of vasodilation positive regulation of long-term neuronal synaptic plasticity lung alveolus development cell maturation branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of epithelial cell proliferation positive regulation of neurogenesis positive regulation of calcium-mediated signaling calcium ion homeostasis response to oxygen levels regulation of hematopoietic progenitor cell differentiation regulation of endothelial cell proliferation protein phosphorylation multicellular organism development phosphorylation cell differentiation positive regulation of vascular endothelial growth factor receptor signaling pathway blood vessel endothelial cell differentiation
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