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Phospho-p130Cas (Tyr249) Antibody (MA5-31563) in IHC (P)
Phospho-p130Cas (Tyr249) Monoclonal Antibody (GT331) detects p130Cas protein at cytoplasm in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. Phospho-p130Cas (Tyr249) Monoclonal Antibody (GT331) (Product # MA5-31563) diluted at 1:200. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
MA5-31563
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
GT331
抗原
Recombinant protein encompassing a sequence within the center region of human p130Cas.
偶联物
形式
Liquid
浓度
1.55 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787191
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (88%), Rat (88%), Bovine (88%).
Positive Control: H1299.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCA1; breast cancer anti-estrogen resistance 1; Breast cancer anti-estrogen resistance protein 1; Cas scaffolding protein family member 1; CRK-associated substrate; Crk-associated substrate p130Cas; OTTHUMP00000174941; p130 Cas; p130cas; p130Cas (pTyr410); p130Cas (pY410); p130Cas phospho; phospho p130Cas; v-crk-associated tyrosine kinase substrate
基因别名: AI385681; BCAR1; CAS; CAS1; CASS1; CRKAS; P130CAS
UniProt ID: (Human) F8WA69, (Mouse) Q61140, (Rat) Q63767
Entrez Gene ID: (Human) 9564, (Mouse) 12927, (Rat) 25414
actin filament organization
cell adhesion
epidermal growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
integrin-mediated signaling pathway
insulin receptor signaling pathway
positive regulation of endothelial cell migration
cell migration
actin cytoskeleton organization
positive regulation of cell migration
cellular response to hepatocyte growth factor stimulus
platelet-derived growth factor receptor signaling pathway
vascular endothelial growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
hepatocyte growth factor receptor signaling pathway
antigen receptor-mediated signaling pathway
B cell receptor signaling pathway
cell chemotaxis
signal transduction
regulation of cell growth
cell proliferation
regulation of apoptotic process
T cell receptor signaling pathway
cell division
