Invitrogen

Phospho-p38 MAPK gamma/delta (Tyr185, Tyr182) Polyclonal Antibody

Phospho-p38 MAPK gamma/delta (Tyr185, Tyr182) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-p38 MAPK gamma/delta (Tyr185, Tyr182) Antibody (PA5-105907) in IHC (P)

Immunohistochemistry analysis of paraffin-embedded Phospho-p38 MAPK gamma/delta (Tyr185, Tyr182) in mouse kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-p38 MAPK gamma/delta (Tyr185, Tyr182) polyclonal antibody (Product # PA5-105907) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjug... View More

Phospho-p38 MAPK gamma/delta (Tyr185, Tyr182) Antibody in Western Blot (WB)

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产品信息

PA5-105907

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human MAPK12(Accession P53778), corresponding to amino acid residues around phosphorylated Tyr185.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2817306

产品详细信息

Antibody detects endogenous levels of p38 gamma/delta only when phosphorylated at Tyr185/182.

靶标信息

Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.

eLife

Romero-Becerra R,Mora A,Manieri E,Nikolic I,Santamans AM,Montalvo-Romeral V,Cruz FM,Rodríguez E,León M,Leiva-Vega L,Sanz L,Bondía V,Filgueiras-Rama D,Jiménez-Borreguero LJ,Jalife J,Gonzalez-Teran B,Sabio G

PA5-105907 was used in Western Blotting to identify a key role for the MKK3/6-p38γ/δ pathway in the development of cardiac hypertrophy, which has important implications for the clinical use of p38α inhibitors in the long-term treatment since they might result in cardiotoxicity.

Tue Aug 16 00:00:00 UTC 2022

MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.

eLife

Tue Aug 16 00:00:00 UTC 2022

生物信息学

蛋白别名: ERK-6; Exon skip; Extracellular signal-regulated kinase 6; MAP kinase 12; MAP kinase 13; MAP kinase p38 delta; MAP kinase p38 gamma; MAPK 12; MAPK 13; mitogen activated protein kinase 12; mitogen activated protein kinase 13; Mitogen-activated protein kinase 12; Mitogen-activated protein kinase 13; mitogen-activated protein kinase 3; Mitogen-activated protein kinase p38 delta; Mitogen-activated protein kinase p38 gamma; p38 delta MAP kinase; SAP kinase-3; SAPK/Erk/kinase 4; stress activated protein kinase 3; Stress-activated protein kinase 3; Stress-activated protein kinase 4

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基因别名: AW123708; ERK-6; ERK3; ERK6; MAPK 12; MAPK 13; MAPK-13; MAPK12; MAPK13; p38delta; P38GAMMA; PRKM12; PRKM13; SAPK-3; SAPK3; SAPK4; Serk4