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Phospho-p47phox (Ser304) Antibody (PA5-105496) in ICC/IF
Immunocytochemistry analysis of Phospho-p47phox (Ser304) in Hela cells (4h of LPS treatment). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Phospho-p47phox (Ser304) polyclonal antibody (Product # PA5-105496) 1:200 and mouse anti-beta tubulin antibody (1:200) for 1 hour at 37°C. An AlexaFluor594 conjugated... View More
产品信息
PA5-105496
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NCF1(Accession P14598), corresponding to amino acid residues around phosphorylated Ser304.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816924
产品详细信息
Antibody detects endogenous levels of NCF1/p47-phox only when phosphorylated at Ser304.
靶标信息
p47phox (NCF1) is required, along with NCF2 and membrane bound cytochrome b558, for activation of the latent NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce superoxide anion. Mutations in the gene can result in granulomatous disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 47 kDa autosomal chronic granulomatous disease protein; 47 kDa neutrophil oxidase factor; NADPH oxidase organizer 2; NCF-1; NCF-47K; neutrop; Neutrophil cytosol factor 1; neutrophil cytosolic factor 1, (chronic granulomatous disease, autosomal 1); Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2; P47 phox; p47-phox; phagocyte oxidase 47 kDa; SH3 and PX domain-containing protein 1A
基因别名: Ncf-1; NCF1; NCF1A; NOXO2; p47phox; SH3PXD1A
UniProt ID: (Human) P14598
Entrez Gene ID: (Human) 653361, (Rat) 114553
response to yeast
leukocyte mediated cytotoxicity
respiratory burst involved in defense response
protein targeting to membrane
leukotriene metabolic process
apoptotic process
inflammatory response
cellular defense response
cell proliferation
response to bacterium
superoxide anion generation
defense response to bacterium
respiratory burst
negative regulation of smooth muscle contraction
hydrogen peroxide biosynthetic process
defense response to Gram-positive bacterium
defense response to fungus
oxidation-reduction process
neutrophil mediated killing of gram-positive bacterium
neutrophil mediated killing of fungus
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
superoxide metabolic process
positive regulation of catalytic activity
innate immune response
cell redox homeostasis
vascular endothelial growth factor receptor signaling pathway
