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Phospho-p70 S6 Kinase (Ser398) Antibody (PA5-95681) in WB
Western blot of p70 S6 Kinase in Drosophila S2 cell lysate showing specific labeling of a band at ~70 kDa corresponding to Phospho-p70 S6 Kinase (Ser398) polyclonal antibody (Product # PA5-95681) in the first lane (-). Immunolabeling is blocked by pre-adsorption with the phosphopeptide used as antigen in the second lane (+), but not by the corresponding non-phosphopeptide (not shown).
产品信息
PA5-95681
产品规格
种属反应
Fruit fly
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr398 conjugated to KLH
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen Affinity Chromatography
保存液
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 150mM NaCl
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2807483
产品详细信息
Antigen Affinity Purified from Pooled Serum
靶标信息
RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CG10539-PA; CG10539-PB; Dp70s6k; dS6 kinase; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase; p70 S6 kinase; p70 S6 kinase 1; p70S6 kinase; p70S6K kinase; p70S6K-alpha; p80-S6K 1; p85 p85S6K; protein kinase-like 64F; ribosomal S6 protein kinase; RPS6-p70-protein kinase; S6 kinase; S6-kinase; S6K kinase; S6k-PA; S6k-PB; S6kinase
基因别名: 10539; 7-10; 7084; CG10539; d-S6K; Dmel\CG10539; Dmel_CG10539; Dp70[s6k]; Dp70S6k; dps6k; DS6K; dS6K1; fs(3)07084; l(3)07084; p-S6K; p70 S6K; p70/S6K; p70[S6 kinase]; p70[S6K]; p70[S6kinase]; p70S6K; Pk64F; Pk?6; S6 K; S6K; S6K1; s6k11; S6k|S6K
Entrez Gene ID: (Fruit fly) 38654
protein phosphorylation
response to oxidative stress
insulin receptor signaling pathway
determination of adult lifespan
positive regulation of autophagy
positive regulation of cell growth
larval feeding behavior
cellular response to insulin stimulus
multicellular organism growth
intracellular signal transduction
female germ-line stem cell population maintenance
TORC1 signaling
positive regulation of cell size
vascular endothelial growth factor receptor signaling pathway
dendrite morphogenesis
synaptic growth at neuromuscular junction
lipid homeostasis
cellular response to amino acid stimulus
positive regulation of axon guidance
regulation of terminal button organization
regulation of response to drug
