Invitrogen

Phospho-p73 (Thr86) Polyclonal Antibody

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抗体检测数据 (1)

Phospho-p73 (Thr86) Antibody in Western Blot (WB)

Phospho-p73 (Thr86) Antibody in Western Blot (WB)

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Phospho-p73 (Thr86) Antibody (PA5-118706) in WB

Western blot analysis of Phospho-p73 (Thr86) in Rat heart using a Phospho-p73 (Thr86) polyclonal antibody (Product # PA5-118706). The lane on the left was treated with blocking peptide.

Phospho-p73 (Thr86) Antibody in Western Blot (WB)

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Phospho-p73 (Thr86) Antibody in Western Blot (WB) — Western blot analysis of Phospho-p73 (Thr86) in Rat heart using a Phospho-p73 (Thr86) polyclonal antibody (Product # PA5-118706). The lane on the left was treated with blocking peptide.

产品信息

PA5-118706

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human TP73(Accession O15350), corresponding to amino acid residues around phosphorylated Thr86.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

AB_2903206

产品详细信息

Antibody detects endogenous levels of p73 only when phosphorylated at Thr86.

靶标信息

P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; RP23-254N4.10; transformation related protein 73; Tumor protein p73

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基因别名: deltaNp73; P73; TAp73; TP73; Trp73

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UniProt ID: (Human) O15350, (Mouse) Q9JJP2

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Entrez Gene ID: (Human) 7161, (Rat) 362675, (Mouse) 22062

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RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding p53 binding chromatin binding damaged DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein kinase binding identical protein binding transcription regulatory region DNA binding metal ion binding DNA binding double-stranded DNA binding sequence-specific DNA binding P53-like transcription factor

negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity kidney development mismatch repair transcription from RNA polymerase II promoter cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle arrest regulation of mitotic cell cycle intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to organonitrogen compound response to gamma radiation regulation of gene expression viral process mitotic G1 DNA damage checkpoint cellular response to UV response to drug intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process negative regulation of JUN kinase activity negative regulation of neuron apoptotic process negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of oligodendrocyte differentiation protein tetramerization negative regulation of cardiac muscle cell proliferation positive regulation of cell cycle arrest positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway regulation of signal transduction by p53 class mediator release of cytochrome c from mitochondria inflammatory response post-embryonic development hippocampus development forebrain development cerebrospinal fluid secretion positive regulation of apoptotic process regulation of neuron apoptotic process positive regulation of cell size digestive tract morphogenesis neuron development positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator positive regulation of apoptotic signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated apoptotic process cell cycle