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产品信息
PA5-42752
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human KLKB1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2609768
产品详细信息
Peptide sequence: VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS
Sequence homology: Dog: 86%; Horse: 86%; Human: 100%; Pig: 79%; Rat: 79%
靶标信息
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: EC 3.4.21.34; Fletcher factor; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; Kininogenin; PKK; Plasma kallikrein; Plasma prekallikrein
基因别名: KLK3; KLKB1; PKK; PKKD; PPK
UniProt ID: (Human) P03952
Entrez Gene ID: (Human) 3818
