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Plasma Kallikrein Antibody (PA5-76711) in IHC (P)
Immunohistochemistry analysis of Plasma Kallikrein in paraffin-embedded human placenta. Samples were incubated with Plasma Kallikrein polyclonal antibody (Product # PA5-76711) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-76711
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human Plasma Kallikrein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720438
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: antigen, prostate specific; EC 3.4.21.34; Fletcher factor; kallikrein 3, plasma; kallikrein B plasma; kallikrein B, plasma (Fletcher factor) 1; Kininogenin; PKK; Plasma kallikrein; Plasma prekallikrein
基因别名: APS; Kal-3; Kal3; Kalp1; KALP15; KLK3; KLKB1; Pk; PKK; PKKD; PPK; PSA
UniProt ID: (Human) P03952, (Mouse) P26262
Entrez Gene ID: (Human) 3818, (Rat) 25048, (Mouse) 16621
