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Invitrogen
Plasminogen Polyclonal Antibody
Product Details
PA5-34677
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fragment corresponding to a region within amino acids 84 and 434 of Plasminogen (Uniprot ID#P00747)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2552029
Product Specific Information
Recommended positive controls: Jurkat, Raji, K562, BCL-1, PC-12, Rat2, human plasma, mouse plasma, rat plasma.
Predicted reactivity: Rat (80%), Dog (81%), Pig (80%), Rhesus Monkey (93%), Bovine (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: angiostatin; DKFZp779M0222; plasmin; plasmin heavy chain A; plasmin light chain B; Plasminogen; RP1-81D8.1
Gene Aliases: Ab1-346; AI649309; Pg; PLG
UniProt ID: (Human) P00747, (Mouse) P20918, (Rat) Q01177
Entrez Gene ID: (Human) 5340, (Mouse) 18815, (Rat) 85253
platelet degranulation
proteolysis
blood coagulation
negative regulation of cell proliferation
negative regulation of cell-substrate adhesion
extracellular matrix disassembly
fibrinolysis
cellular protein metabolic process
tissue remodeling
negative regulation of fibrinolysis
positive regulation of fibrinolysis
negative regulation of cell-cell adhesion mediated by cadherin
hemostasis
negative regulation of angiogenesis
tissue regeneration
myoblast differentiation
muscle cell cellular homeostasis
proteolysis involved in cellular protein catabolic process
trophoblast giant cell differentiation
labyrinthine layer blood vessel development
mononuclear cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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