Alomone Labs, LTD

Platelet-activating factor receptor (extracellular) Polyclonal Antibody, FITC

View all (9) PTAFR antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

APR-055-F-50UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)ELGYQTNFHQAINDAH, corresponding to amino acid residues 259-274 of mouse PTAFR, Extracellular, 3rd loop
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Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Lyophilized

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

PTAFR shows structural characteristics of the rhodopsin gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: PAF receptor; PAF-R; PAFr; Platelet-activating factor receptor

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Gene Aliases: PAFR; PTAFR

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UniProt ID: (Human) P25105, (Mouse) Q62035, (Rat) P46002

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Entrez Gene ID: (Human) 5724, (Mouse) 19204, (Rat) 58949

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Function(s)
lipopolysaccharide binding lipopolysaccharide receptor activity G-protein coupled receptor activity platelet activating factor receptor activity phospholipid binding G-protein coupled purinergic nucleotide receptor activity mitogen-activated protein kinase binding signal transducer activity G-protein coupled receptor
Process(es)
cytokine production regulation of transcription from RNA polymerase II promoter chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway parturition response to symbiotic bacterium positive regulation of phospholipase C activity lipopolysaccharide-mediated signaling pathway positive regulation of tumor necrosis factor production inositol trisphosphate biosynthetic process G-protein coupled purinergic nucleotide receptor signaling pathway positive regulation of neutrophil degranulation transcytosis positive regulation of interleukin-6 biosynthetic process positive regulation of translation negative regulation of blood pressure positive regulation of vasoconstriction positive regulation of vasodilation phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation interferon-gamma-mediated signaling pathway positive regulation of inositol phosphate biosynthetic process cellular response to gravity cellular response to cAMP cellular response to fatty acid response to dexamethasone positive regulation of voltage-gated chloride channel activity positive regulation of leukocyte tethering or rolling positive regulation of sensory perception of pain positive regulation of transcytosis positive regulation of maternal process involved in parturition positive regulation of gastro-intestinal system smooth muscle contraction cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine pattern recognition receptor signaling pathway signal transduction response to lipopolysaccharide
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