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Alomone Labs, LTD
Platelet-activating factor receptor (extracellular) Polyclonal Antibody, FITC
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Platelet-activating factor receptor (extracellular) Antibody (APR-055-F-50UL) in Flow
Cell surface detection of PAFR by direct flow cytometry in live intact human MEG-01 megakaryoblastic leukemia cells: - (black line) cells. (red) Cells + Rabbit IgG Isotype Control-FITC. (green) Cells + Anti-Platelet-activating factor receptor (extracellular)-FITC Antibody (#APR-055-F), (2.5 µg).
产品信息
APR-055-F-50UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)ELGYQTNFHQAINDAH, corresponding to amino acid residues 259-274 of mouse PTAFR, Extracellular, 3rd loop
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
PTAFR shows structural characteristics of the rhodopsin gene family and binds platelet-activating factor (PAF). PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) that has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PAF receptor; PAF-R; PAFr; Platelet-activating factor receptor
基因别名: PAFR; PTAFR
UniProt ID: (Human) P25105, (Mouse) Q62035, (Rat) P46002
Entrez Gene ID: (Human) 5724, (Mouse) 19204, (Rat) 58949
lipopolysaccharide binding
lipopolysaccharide receptor activity
G-protein coupled receptor activity
platelet activating factor receptor activity
phospholipid binding
G-protein coupled purinergic nucleotide receptor activity
mitogen-activated protein kinase binding
signal transducer activity
G-protein coupled receptor
cytokine production
regulation of transcription from RNA polymerase II promoter
chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
parturition
response to symbiotic bacterium
positive regulation of phospholipase C activity
lipopolysaccharide-mediated signaling pathway
positive regulation of tumor necrosis factor production
inositol trisphosphate biosynthetic process
G-protein coupled purinergic nucleotide receptor signaling pathway
positive regulation of neutrophil degranulation
transcytosis
positive regulation of interleukin-6 biosynthetic process
positive regulation of translation
negative regulation of blood pressure
positive regulation of vasoconstriction
positive regulation of vasodilation
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
interferon-gamma-mediated signaling pathway
positive regulation of inositol phosphate biosynthetic process
cellular response to gravity
cellular response to cAMP
cellular response to fatty acid
response to dexamethasone
positive regulation of voltage-gated chloride channel activity
positive regulation of leukocyte tethering or rolling
positive regulation of sensory perception of pain
positive regulation of transcytosis
positive regulation of maternal process involved in parturition
positive regulation of gastro-intestinal system smooth muscle contraction
cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
pattern recognition receptor signaling pathway
signal transduction
response to lipopolysaccharide
