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Invitrogen
Pleiotrophin Polyclonal Antibody
FIGURE: 1 / 3
Pleiotrophin Antibody (PA5-118876) in WB
Western blot of Pleiotrophin (PTN) was performed by loading 25 µg of serum free concentrated culture media from U-87MG WT (lane 1) and PTN KO (lane 2) cells onto a NuPAGE™ 10%, Bis-Tris, 1.0 mm, Midi Protein Gel (Product # WG1201BOX). Proteins on the blot were visualized with Ponceau staining (below immunoblot). Proteins were transferred to nitrocellulose membrane and blocked in 5% milk for 1 hr. PTN was detected at approximately 19 kDa using Pleiotrophin Polyclonal Antibody (Product # PA5-118876) at a dilution of 1:500 in 5% BSA in TBST f... View More
Product Details
PA5-118876
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTN(Accession P21246), corresponding to amino acid residues K139-D168.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903376
Product Specific Information
Antibody detects endogenous levels of total PTN.
Target Information
Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HB-GAM; HBBM; HBGF-8; HBNF; HBNF-1; heparin affin regulatory peptide; heparin affin regulatory protein; heparin binding factor; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; heparin-binding neurite promoting factor; heparin-binding neurotorphic factor; Heparin-binding neutrophic factor; OSF-1; Osteoblast-specific factor 1; osteoblastic cell factor; Pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); Pleiotrophin (Heparine binding factor, Hbnf, in the mouse); PTN
Gene Aliases: HARP; HB-GAM; HBBM; HBBN; HBGF-8; HBGF8; HBNF; HBNF-1; HBNF1; NEGF1; OSF; OSF-1; Osf1; PTN
UniProt ID: (Human) P21246, (Rat) P63090, (Mouse) P63089
Entrez Gene ID: (Human) 5764, (Rat) 24924, (Mouse) 19242
liver development
transmembrane receptor protein tyrosine phosphatase signaling pathway
nervous system development
heart development
learning
positive regulation of cell proliferation
regulation of cell shape
positive regulation of cell-substrate adhesion
positive regulation of neuron projection development
response to activity
negative regulation of angiogenesis
spinal cord development
cerebellum development
thalamus development
bone mineralization
lung development
negative regulation of cell migration
response to estradiol
response to progesterone
cellular response to UV
cellular response to platelet-derived growth factor stimulus
response to drug
positive regulation of apoptotic process
negative regulation of catalytic activity
estrous cycle
endothelial cell differentiation
negative regulation of membrane potential
negative regulation of epithelial cell proliferation
positive regulation of cell division
retinal rod cell differentiation
negative regulation of glial cell proliferation
long-term synaptic potentiation
cellular response to vitamin D
cellular response to hypoxia
negative regulation of mesenchymal cell proliferation
response to kainic acid
rod bipolar cell differentiation
response to ciliary neurotrophic factor
positive regulation of skeletal muscle acetylcholine-gated channel clustering
negative regulation of neuromuscular junction development
response to nerve growth factor
positive regulation of hepatocyte proliferation
ossification
neuromuscular junction development
skeletal muscle acetylcholine-gated channel clustering
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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