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Plexin-A3 (extracellular) Antibody (APR-093-200UL) in IHC (F)
Expression of Plexin-A3 in mouse parietal cortex - Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-Plexin-A3 (extracellular) Antibody (#APR-093), (1:200), followed by goat- Anti-rabbit-AlexaFluor-488. PLXNA3 staining (green) appears in pyramidal neurons (arrows). Cell nuclei are stained with DAPI (blue).
Product Details
APR-093-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KVRVDGSQDAQLYE, corresponding to amino acid residues 440-453 of mouse PLXNA3, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: plexin 3; Plexin 4, SEX, homolog to the cMet/HGF receptors; Plexin-4; Plexin-A3; Semaphorin receptor SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; SEXPLEXIN-A3
Gene Aliases: 6.3; HSSEXGENE; mKIAA4078; PlexA3; Plxa3; PLXN3; PLXN4; PLXNA3; SEX; XAP-6
UniProt ID: (Human) P51805, (Mouse) P70208, (Rat) D3ZPX4
Entrez Gene ID: (Human) 55558, (Mouse) 18846, (Rat) 309280
signal transduction
axon guidance
facial nerve structural organization
trigeminal nerve structural organization
hippocampus development
branchiomotor neuron axon guidance
pyramidal neuron development
negative regulation of axon extension involved in axon guidance
negative chemotaxis
positive regulation of cytoskeleton organization
semaphorin-plexin signaling pathway involved in axon guidance
semaphorin-plexin signaling pathway
multicellular organism development
regulation of cell migration
regulation of axon extension involved in axon guidance
neuron projection extension
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