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Podoplanin Antibody (MA5-16267) in ICC/IF
Immunofluorescence analysis of Podoplanin was performed using 70 % confluent log phase HEK-293 cells. The cells were fixed with 4 % paraformaldehyde for 10 minutes, permeabilized with 0.1 % Triton™ X-100 for 15 minutes, and blocked with 2 % BSA for 45 minutes at room temperature. The cells were labeled with Podoplanin Monoclonal Antibody (NZ-1.2) (Product # MA5-16267) at 10 µg/mL in 0.1% BSA, incubated at 4... View More
产品信息
MA5-16267
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rat
/ IgG2a, lambda
分类
Monoclonal
类型
Antibody
克隆号
NZ-1.2
抗原
Synthetic peptide corresponding to amino acids 38-70 (EGGVAMPGAEDDVV) from the platelet-aggregation-stimulating (PLAG) domain of human podoplanin
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2537784
靶标信息
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; Glycoprotein 36; glycoprotein, 36-KD; Gp36; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTTHUMP00000009640; OTTHUMP00000044504; PA2.26 antigen; PDPN; PICD; Podoplanin; RP23-348F1.2; T1-alpha; T1A
基因别名: AGGRUS; GP36; Gp38; GP40; HT1A-1; OTS8; PA2.26; PDPN; PSEC0003; PSEC0025; T1A; T1A-2; T1A2; TI1A
UniProt ID: (Human) Q86YL7
Entrez Gene ID: (Human) 10630
cell morphogenesis
lymphangiogenesis
prostaglandin metabolic process
water transport
amino acid transport
signal transduction
cell proliferation
regulation of cell shape
folic acid transport
single organismal cell-cell adhesion
platelet activation
lung development
lung alveolus development
cell motility
positive regulation of cellular component movement
regulation of G1/S transition of mitotic cell cycle
