Invitrogen

Procollagen I N-Peptide Polyclonal Antibody

Procollagen I N-Peptide Antibody in Immunohistochemistry (IHC)

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Procollagen I N-Peptide Antibody (PA5-35379) in IHC

Immunohistochemistry analysis of COL1A1 Propeptide in fibrotic mouse lung tissue showing specific staining of COL1A1 Propeptide polyclonal antibody (Product # PA5-35379) using a dilution of 1:100 (red) that are still associated with the cells in which they were synthesized. The blue is staining DNA.

Procollagen I N-Peptide Antibody in Western Blot (WB)

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产品信息

PA5-35379

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

- -

免疫组化 (IHC)

1:100

免疫组化（冰冻） (IHC (F))

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acid residues specific to human collagen 1, alpha 1 propeptide conjugated to KLH

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

~0.15 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.5

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2552689

产品详细信息

This antibody is predicted to react with most mammals, birds, amphibians and fish based on 100% sequence homology.

This antibody contains enough material to conduct 10 mini-Western blots.

靶标信息

Procollagen type I N-terminal propeptide (P1NP) is a specific marker of bone formation, reflecting the synthesis of type I collagen, which constitutes the major part of the bone matrix. P1NP is derived during the conversion of procollagen to collagen, produced by osteoblasts during bone formation. Its primary clinical application lies in the diagnosis and monitoring of metabolic bone diseases, particularly osteoporosis. In osteoporotic patients, P1NP levels can predict bone mineral density (BMD) responses to treatments like teriparatide and romosozumab. Low serum levels of P1NP are indicative of a high risk of BMD loss, providing a valuable tool for premenopausal women with systemic lupus erythematosus (SLE) and other conditions affecting bone health.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The mononuclear phagocyte system contributes to fibrosis in post-transplant obliterans bronchiolitis.

The European respiratory journal

Di Campli MP,Azouz A,Assabban A,Scaillet J,Splittgerber M,Van Keymeulen A,Libert F,Remmelink M,Le Moine A,Lemaitre P,Goriely S

PA5-35379 was used in Immunohistochemistry (Frozen) to conclude that therapies targeting the mononuclear phagocyte system could improve long-term outcomes after lung transplantation.

Mon Mar 01 00:00:00 UTC 2021

生物信息学

蛋白别名: alpha-1 type 1 collagen; Alpha-1 type I collagen; alpha1(I) procollagen; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; collagen of skin, tendon and bone, alpha-1 chain; collagen, type 1, alpha 1; collagen, type I, alpha 1; P1NP; pro-alpha-1 collagen type 1; Procollagen I N; procollagen type I, alpha 1; procollagen, type 1, alpha 1; procollagen, type I, alpha 1; type I proalpha 1; type I procollagen alpha 1 chain; type I-alpha 1 collagen

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基因别名: Col1a-1; COL1A1; Cola-1; Cola1; COLIA1; EDSC; Mov-13; Mov13; OI1; OI2; OI3; OI4

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UniProt ID: (Human) P02452, (Rat) P02454, (Mouse) P11087

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Entrez Gene ID: (Human) 1277, (Rat) 29393, (Mouse) 12842

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功能

extracellular matrix structural constituent protein binding identical protein binding metal ion binding platelet-derived growth factor binding molecular_function extracellular matrix structural protein

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