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Invitrogen
Prolactin Receptor Recombinant Rabbit Monoclonal Antibody (ARC2123)
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Prolactin Receptor Antibody (MA5-38107) in ICC/IF
Immunofluorescence analysis of Prolactin Receptor was performed using 70% confluent log phase T-47D and MCF 10A cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.01% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Prolactin Receptor Recombinant Rabbit Monoclonal Antibody (ARC2123) (Product # MA5-381... View More
产品信息
MA5-38107
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2123
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Prolactin Receptor (P16471)
偶联物
形式
Liquid
浓度
0.55 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898025
产品详细信息
Positive Samples: HepG2, BT-474, MCF7
Immunogen sequence: MKENVASATV FTLLLFLNTC LLNGQLPPGK PEIFKCRSPN KETFTCWWRP GTDGGLPTNY SLTYHREGET LMHECPDYIT GGPNSCHFGK QYTSMWRTYI
靶标信息
Prolactin (PRL) is a pituitary hormone involved in the stimulation of milk production, salt and water regulation, growth, development and reproduction. PRL exerts its influence on different cell types through a signal transduction pathway which begins with the binding of the hormone to a transmembrane PRL receptor. Immunoreactive PRL receptor (PRLR), a member of the cytokine receptor family, varies in size (short and long forms) with tissue source and species, from ~40 kDa to 100 kDa. PRLR consists of at least three separate domains: an extracellular region with 5 cysteines which contains the prolactin binding site, a single transmembrane domain and a cytoplasmic region, the length of which appears to influence ligand binding and regulate cellular function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hPRL receptor; Lactogen receptor; Prl R; PRL-R; Prolactin receptor; prolactin receptor related sequence 1; secreted prolactin binding protein
基因别名: AI987712; HPRL; hPRLrI; MFAB; Pr-1; Pr-3; PRLR; Prlr-rs1; RATPRLR
UniProt ID: (Human) P16471, (Rat) P05710, (Mouse) Q08501
Entrez Gene ID: (Human) 5618, (Rat) 24684, (Mouse) 19116
steroid biosynthetic process
cell surface receptor signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
embryo implantation
lactation
regulation of cell adhesion
regulation of epithelial cell differentiation
prolactin signaling pathway
T cell activation
activation of JAK2 kinase activity
negative regulation of apoptotic process
JAK-STAT cascade involved in growth hormone signaling pathway
mammary gland epithelial cell differentiation
prostate gland growth
mammary gland alveolus development
JAK-STAT cascade
cytokine-mediated signaling pathway
mammary gland epithelium development
