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产品信息
PA5-77976
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human Prothrombin. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2736466
产品详细信息
Positive Control: 293T, A431, human plasma, mouse plasma, rat plasma
Predicted Reactivity: Rhesus Monkey (96%), Bovine (80%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: coagulation factor 2; Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine protease; thrombin
基因别名: Cf-2; Cf2; F2; FII; PT; RPRGL2; THPH1
UniProt ID: (Mouse) P19221, (Human) P00734
Entrez Gene ID: (Mouse) 14061, (Rat) 29251, (Human) 2147
positive regulation of protein phosphorylation
proteolysis
acute-phase response
cell surface receptor signaling pathway
blood coagulation
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
platelet activation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
wound healing
fibrinolysis
negative regulation of proteolysis
negative regulation of astrocyte differentiation
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
signal peptide processing
ER to Golgi vesicle-mediated transport
multicellular organism development
blood coagulation, intrinsic pathway
negative regulation of platelet activation
peptidyl-glutamic acid carboxylation
regulation of blood coagulation
cellular protein metabolic process
leukocyte migration
negative regulation of fibrinolysis
