Invitrogen

Pyruvate Carboxylase Polyclonal Antibody

Pyruvate Carboxylase Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 9

Pyruvate Carboxylase Antibody (PA5-60552) in ICC/IF

Immunofluorecent analysis of Pyruvate Carboxylase in human cell line A549 using Pyruvate Carboxylase Polyclonal Antibody (Product # PA5-60552). Staining shows localization to mitochondria.

Pyruvate Carboxylase Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Pyruvate Carboxylase Antibody in Western Blot (WB)

Product Image Gallery

产品信息

PA5-60552

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:50

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human Pyruvate Carboxylase. Recombinant protein control fragment (Product #RP-97479).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2646175

产品详细信息

Immunogen sequence: GADVVDVAAD SMSGMTSQPS MGALVACTRG TPLDTEVPME RVFDYSEYWE GARGLYAAFD CTATMKSGNS DVYENEIPGG QYTNLHFQ

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

靶标信息

Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.

仅用于科研。不用于诊断过程。未经明确授权不得转售。