Search Thermo Fisher Scientific
Immunogen sequence: FAHFKDFTATF GPLDSLNTRL FLQGPKIAEE FEVELERGKT LHIKALAVSD LNRAGQRQVF FELNGQLRSI LVKDTQAMKE MHFHPKALKD VKGQIG
Highest antigen sequence identity to the following orthologs - mouse 99%, rat 99%.
Pyruvate Carboxylase requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EC 6.4.1.1; PCB; PYC; Pyruvate carboxylase, mitochondrial; Pyruvic carboxylase
基因别名: PC; PCB
UniProt ID: (Human) P11498
Entrez Gene ID: (Human) 5091