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Immunogen sequence: LRKKVFEKDF GPIDPECTCP TCQKHSRAFL HALLHSDNTA ALHHLTVHNI AYQLQLMSAV RTSIVEKRFP DFVRDFMGAM YGDPTLCPTW A
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 76%.
tRNA-guanine transglycosylase (TGT; EC 2.4.2.29) synthesizes queuosine (Q), which is found in tRNAs that recognize NAU and NAC codons, encoding tyr, asn, asp, and his. Prokaryotic TGT is a single protein of 43 kD. In contrast, mammalian TGT appears to be a heterodimer consisting of a 60-kD subunit (USP14; MIM 607274) and a 43-kD catalytic subunit (QTRT1) (Deshpande and Katze, 2001 [PubMed 11255023]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Guanine insertion enzyme; queuine tRNA-ribosyltransferase 1; Queuine tRNA-ribosyltransferase catalytic subunit 1; TGT, 43-KD subunit; TGT, catalytic subunit; tRNA-guanine transglycosylase
Gene Aliases: FP3235; QTRT1; TGT; TGUT
UniProt ID: (Human) Q9BXR0
Entrez Gene ID: (Human) 81890
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