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产品信息
PA5-115818
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RAB23(Accession Q9ULC3), corresponding to amino acid residues E179-N229.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900452
产品详细信息
Antibody detects endogenous levels of total RAB23.
靶标信息
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 23, also known as HSPC137, is a 237 amino acid member of the Rab family of proteins and localizes to the cytoplasmic side of the cell membrane. Rab 23 is believed to play a role in intracellular protein transportation and signal transduction mediated by small GTPases. Mutations in the gene encoding Rab 23 may result in Carpenter syndrome, also known as ACPS2 (acrocephalopolysyndactyly type 2), a condition characterized by obesity, cardiac defects, polysyndactyly and craniosynostosis.
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生物信息学
蛋白别名: DKFZp781H0695; MGC8900; open brain 2; OTTHUMP00000040021; protein open brain; RAB 23; RAB family small GTP binding protein RAB 23; rab-15; Ras-related protein Rab-23; RP3-496N17.3
基因别名: AW545388; HSPC137; opb; opb2; RAB23
UniProt ID: (Human) Q9ULC3
Entrez Gene ID: (Human) 51715, (Mouse) 19335
autophagosome assembly
neural tube closure
transport
intracellular protein transport
cellular defense response
signal transduction
small GTPase mediated signal transduction
multicellular organism development
nervous system development
regulation of smoothened signaling pathway
protein transport
spinal cord dorsal/ventral patterning
dorsal/ventral neural tube patterning
Rab protein signal transduction
cilium assembly
embryonic digit morphogenesis
negative regulation of transcription factor import into nucleus
negative regulation of proteolysis
craniofacial suture morphogenesis
