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产品信息
PA5-109243
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within Human Rae1 aa 319-368
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2854654
产品详细信息
Positive Control: PC-3, mouse testis tissue, rat testis tissue, LOVO, MCF-7, PC-3M.
靶标信息
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
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生物信息学
蛋白别名: FLJ30608; HGNC:9828; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer); MGC117333; MGC126076; MGC126077; migration-inducing gene 14; mRNA export factor RAE1; mRNA export protein; mRNA-associated protein MRNP 41; mRNA-binding protein, 41-kD; OTTHUMP00000166110; Rae1 protein homolog; RAE1 RNA export 1 homolog; RP4-800J21.2
基因别名: dJ481F12.3; dJ800J21.1; MIG14; Mnrp41; MRNP41; RAE1
UniProt ID: (Human) P78406
Entrez Gene ID: (Human) 8480
transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
mRNA export from nucleus
tRNA export from nucleus
protein import into nucleus
mitotic nuclear envelope disassembly
regulation of glucose transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
cellular response to organic cyclic compound
intracellular transport of virus
regulation of cellular response to heat
