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产品信息
MA5-17163
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1D9
抗原
Purified recombinant fragment of human RAG1 (amino acids: 818-868) expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538634
产品详细信息
MA5-17163 targets RAG1 in indirect ELISA and WB applications and shows reactivity with Human samples.
The MA5-17163 immunogen is purified recombinant fragment of human RAG1 (amino acids: 818-868) expressed in E. Coli.
MA5-17163 detects RAG1 which has a predicted molecular weight of approximately 119kDa.
靶标信息
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC43321; RAG-1; RAG-1 Antibody; recombination activating gene 1 Antibody; recombination activating protein 1; RING finger protein 74; RNF74 Antibody; V(D)J recombination-activating protein 1
基因别名: RAG-1; RAG1; RNF74
UniProt ID: (Human) P15918
Entrez Gene ID: (Human) 5896
DNA binding
endonuclease activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
histone binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
ubiquitin protein ligase activity
DNA metabolism protein
endodeoxyribonuclease
nucleic acid metabolism protein
adaptive immune response
pre-B cell allelic exclusion
DNA recombination
immune response
histone monoubiquitination
B cell differentiation
T cell differentiation in thymus
V(D)J recombination
T cell homeostasis
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of T cell differentiation
thymus development
protein autoubiquitination
negative regulation of thymocyte apoptotic process
nucleic acid phosphodiester bond hydrolysis
