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RAGE Antibody (MA5-49253) in IHC (P)
Immunohistochemistry analysis of RAGE in paraffin-embedded section of mouse lung tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with RAGE Monoclonal antibody (Product # MA5-49253) using a dilution of 2 μg/mL overnight at 4°C. Peroxidase Conjugated Goat Anti-mouse IgG was use... View More
产品信息
MA5-49253
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
5C6C1
抗原
A synthetic peptide corresponding to a sequence at the N-terminus of human RAGE (91-120aa IQDEGIFRCQAMNRNGKETKSNYRVRVYQI).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074911
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Immunogen sequence is different from the related mouse and rat sequences by six amino acids.
靶标信息
Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: advanced glycation end-products receptor; Advanced glycosylation end product-specific receptor; advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; RAGE-4 ORF3; receptor for advanced glycation end-products variant 20; Receptor for advanced glycosylation end products; sRAGE
基因别名: AGER; RAGE; SCARJ1
UniProt ID: (Human) Q15109, (Mouse) Q62151
Entrez Gene ID: (Human) 177, (Rat) 81722, (Mouse) 11596
regulation of T cell mediated cytotoxicity
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
negative regulation of endothelial cell proliferation
inflammatory response
negative regulation of cell adhesion
cell surface receptor signaling pathway
JAK-STAT cascade
brain development
glycoprotein metabolic process
response to wounding
response to fructose
positive regulation of autophagy
negative regulation of endothelial cell migration
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of fibroblast migration
response to activity
positive regulation of smooth muscle cell migration
lung development
neuron projection development
negative regulation of interleukin-10 production
positive regulation of interleukin-12 production
negative regulation of collagen biosynthetic process
response to vitamin A
response to genistein
negative regulation of osteoblast proliferation
cellular response to drug
positive regulation of activated T cell proliferation
positive regulation of neuron apoptotic process
innate immune response
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
response to methylglyoxal
calcium ion homeostasis
response to hyperoxia
positive regulation of phagocytosis, engulfment
transdifferentiation
cellular response to hydrogen peroxide
cellular response to glucose stimulus
cellular response to fatty acid
cellular response to organic cyclic compound
response to selenite ion
positive regulation of potassium ion transmembrane transporter activity
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
regulation of CD4-positive, alpha-beta T cell activation
positive regulation of type B pancreatic cell apoptotic process
positive regulation of dendritic cell differentiation
response to hypoxia
positive regulation of cell migration
positive regulation of apoptotic process
positive regulation of JUN kinase activity
regulation of inflammatory response
induction of positive chemotaxis
regulation of DNA binding
protein localization to membrane
positive regulation of neuron death
