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RALA Antibody (MA5-31891) in ICC/IF
Immunocytochemistry analysis of RALA in Hela cells (green). Sample was incubated with RALA monoclonal antibody (Product # MA5-31891) using a dilution of 1:200-1:1000 followed by DRAQ5 fluorescent DNA dye (blue), and Alexa Fluor- 555 phalloidin (red labeled actin filaments) .
产品信息
MA5-31891
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
4G8C7
抗原
Purified recombinant fragment of human RALA (AA: 71-203) expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787514
产品详细信息
MA5-31891 has been tested in indirect ELISA.
靶标信息
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC48949; ral-A protein; Ras family small GTP binding protein RALA; ras related GTP binding protein A; RAS-like protein A; RAS-like, family 1; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
基因别名: 3010001O15Rik; AW322615; RAL; Ral-a; RALA; Rasl1
UniProt ID: (Human) P11233, (Mouse) P63321
Entrez Gene ID: (Human) 5898, (Mouse) 56044
cytokinesis
neural tube closure
exocytosis
chemotaxis
signal transduction
Ras protein signal transduction
viral process
regulation of exocytosis
actin cytoskeleton reorganization
positive regulation of filopodium assembly
membrane raft localization
membrane organization
cell cycle
small GTPase mediated signal transduction
cell division
