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RALBP1 Antibody (PA5-106868) in IHC (P)
Immunohistochemistry analysis of RALBP1 in mouse testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with RALBP1 polyclonal antibody (Product # PA5-106868) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-106868
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RALBP1(Accession Q15311), corresponding to amino acid residues L24-K74.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854532
产品详细信息
Antibody detects endogenous levels of total RALBP1.
靶标信息
Can specifically activate hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 76 kDa Ral-interacting protein; Cytocentrin; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1; RalA-binding protein 1; RalBP1; RIP
基因别名: RALBP1; RIP1; RLIP; RLIP1; RLIP76
UniProt ID: (Human) Q15311, (Rat) Q62796, (Mouse) Q62172
Entrez Gene ID: (Human) 10928, (Rat) 84014, (Mouse) 19765
transport
endocytosis
chemotaxis
signal transduction
small GTPase mediated signal transduction
regulation of GTPase activity
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
transmembrane transport
mitotic spindle organization
mitotic nuclear division
metabolic process
negative regulation of smooth muscle cell proliferation
cell division
