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Product Details
PA5-115823
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RAMP1(Accession O60894), corresponding to amino acid residues C82-L132.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900457
Product Specific Information
Antibody detects endogenous levels of total RAMP1.
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcitonin receptor-like receptor activity modifying protein 1; Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1; MGC38240; receptor (calcitonin) activity modifying protein 1; receptor (G protein-coupled) activity modifying protein 1; Receptor activity-modifying protein 1
Gene Aliases: 9130218E19Rik; RAMP1
UniProt ID: (Human) O60894, (Rat) Q9JJ74, (Mouse) Q9WTJ5
Entrez Gene ID: (Human) 10267, (Rat) 58965, (Mouse) 51801
angiogenesis
calcium ion transport
intracellular protein transport
G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
protein transport
positive regulation of cAMP biosynthetic process
receptor internalization
positive regulation of protein glycosylation
protein localization to plasma membrane
signal transduction
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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